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On Tuesday, a seven judge Bench of the Supreme Court, which is currently hearing oral arguments in two cases Abhiram Singh v. Commachen and Narayan Singh v. Verma in December 1995. Around 39 million prescriptions for antidepressants were issued in the community in England in 2009 across all ages, an increase of 35% over five years.3 Prescriptions increased most for the class of selective serotonin reuptake inhibitor antidepressants a 47% increase over five years, compared with an 18% increase for the class of tricyclic and related antidepressants and a 37% increase for other antidepressants.4 5 A systematic review in older people found that tricyclic antidepressants and selective serotonin reuptake inhibitors were equivalent in terms of efficacy but that classic tricyclic antidepressants were associated with a higher discontinuation rate owing to side effects.6 The National Institute for Health and Clinical Excellence recommends that the choice of an antidepressant should be guided by consideration of side effects and the patient’s preferences but that normally a selective serotonin reuptake inhibitor in generic form should be chosen.7Little is known about more serious adverse effects of antidepressants, particularly in older people, in whom adverse drug events may be more common in the treatment of depression compared with younger groups because of higher levels of comorbidity http://www.pandorajewellry-canada.com, age related physiological changes, and polypharmacy.8 The under representation of older people in clinical trials of antidepressants and the fact that most such trials are short term make deriving reliable or precise estimates of the incidence of adverse events in this group difficult.9 10 This problem is further compounded when criteria for trials exclude older people with comorbid conditions.11 Although several observational studies have examined different adverse outcomes associated with use of antidepressants,12 few have been specific to an older population.We therefore did a large cohort study of antidepressant use in older people to investigate the association between antidepressant treatment and risk of several potential adverse outcomes. We directly compared antidepressant class effects and examined dose and associations with use of commonly prescribed individual drugs. We aimed to derive a comprehensive and integrated picture of the relative safety and balance of risks for antidepressant drugs in older people diagnosed as having depression.MethodsFull details of the study methods are published in a Health Technology Assessment monograph.13 We report the key findings of the study here, and further results are presented in the full report.SettingIn summary, we used the QResearch primary care research database (version 22) to do a cohort study in a large population of primary care patients.

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