The results were similar in past users (odds ratio 1.56, 1.23 to 1.98) and recent users (1.48, 0.83 to 2.63) but reached significance only for past users.Conclusions In this prospective population based study https://www.pandoragroupuk.com/, new use of benzodiazepines was associated with increased risk of dementia. The result was robust in pooled analyses across cohorts of new users of benzodiazepines throughout the study and in a complementary case control study. Considering the extent to which benzodiazepines are prescribed and the number of potential adverse effects of this drug class in the general population, indiscriminate widespread use should be cautioned against.IntroductionPrimarily indicated for treating the symptoms of anxiety and sleep disorders over short periods pandora essence,1 benzodiazepines are widely prescribed in developed countries.2 3 In France, 30% of people aged 65 years and over use benzodiazepines.4 They are used by more than 20% of people aged 65 and over in Canada and Spain and by around 15% of those in Australia.5 6 7 Benzodiazepine use is less widespread but still high in elderly people in the United States and the United Kingdom.8 9 Consumption of benzodiazepines is often chronic,2 10 and many people take them for years despite the existence of good practice guidelines suggesting that the duration should be limited to a few weeks.1 10 11 12The short term effects of benzodiazepines on cognition are well known.13 14 15 16 They are mediated through an agonist action on receptors of aminobutyric acid A, a major inhibitory neurotransmitter in the brain.
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